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Profiling extracellular vesicle release by the filarial nematode Brugia malayi reveals sex-specific differences in cargo and a sensitivity to ivermectin.

The filarial nematode Brugia malayi is an etiological agent of Lymphatic Filariasis.The capability of B.malayi and other parasitic nematodes to modulate host biology is recognized but the mechanisms by which such manipulation occurs are obscure.An emerging paradigm is the release of parasite-derived extracellular vesicles (EV) containing bioactive

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Thioridazine reverts the phenotype in cellular and Drosophila models of amyotrophic lateral sclerosis by enhancing TDP-43 aggregate clearance

Brain inclusions mainly composed of misfolded and aggregated TAR DNA binding protein 43 (TDP-43), are characteristic hallmarks of amyotrophic lateral sclerosis (ALS).Irrespective of the role played by the inclusions, 30x24x24 wall cabinet their reduction represents an important therapeutic pathway that is worth exploring.Their removal can either le

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Municipalities without elected councils. Causes of insufficient fulfilment of candidate lists in some municipalities in local elections in 2018

By means of a qualitative analysis of the sixteen municipalities in the Czech Republic in which additional elections were held in 2019, five variables were identified which bolia outlet gent may explain why additional elections occurred.For analysis, we used data from the Czech Statistical Office (municipal elections 1994 to 2019), the Ministry of

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